High Cholesterol? Consider these alternatives


Thirty one point seven percent of the population in the United States has raised cholesterol.  That is about 73.5 million adults.  Recently, we have seen a change in disease burden from infections disease to chronic disease like heart disease. Part of the reason is raised cholesterol due to a diet high in transfats and sugar. Our foods are laced with this stuff and we have no idea. Because of this fact we have statistics like the following: fewer than 1 out of every 3 adults (29.5%) with high LDL cholesterol has the condition under control (CDC).


I’m here to tell you about some popular alternative treatments. First, it is important to know the mechanism by which cholesterol becomes out of whack. Normal LDL and HDL cholesterol levels range between less than 100mg/dL to 129mg/dL and 40mg/dL to greater than 60mg/dL, respectively. Problems may occur when a disproportionate amount of LDL is made when HMGCo-A reductase causes the overproduction of LDL (NIH). LDL, as many of us know, is low-density lipoprotein or “lowsy” lipoprotein.  It is nick-named this because when it becomes damaged, it contributes to arterial plaque.


Some herbs act like HMGCo-A reductase inhibitors.  Two of these are artichoke and Red Yeast Rice. Vitamin B3 is even known to act through the HMGCo-A mechanism, though whether or not it inhibits it is unclear. Other people use fiber so soak up fat from fatty meals in the intestines.


Artichoke is also known as a choleretic.  This means it induces the production of bile acids. For this reason, people with gallstones are cautioned against artichoke. But, artichoke has been found to reduce total cholesterol in adults. In a study of 75 randomized volunteers with cholesterol levels suitable for the study (6.0-8.0mmol/l), it was found plasma total cholesterol reduced in 4.2%. This was a randomized double-blind placebo controlled trial in which the placebo group of experienced an average increase in plasma total cholesterol by 1.9% (Bundy et al). So, there was a statistically significant difference between the results of the two groups. In another study, rats were fed a high cholesterol diet and treated with artichoke extract. It was found serum cholesterol and triglyceride levels and ratio of cholesterol with high-density lipoprotein (HDL)-cholesterol decreased; but liver cholesterol and triglyceride levels remained unchanged (Kucukgergin et al).


Red Yeast rice is a classic HMGCo-A reductase inhibitor used for centuries in China. It is a great alternative for people intolerant of traditional statins. One study found: “Red yeast rice and therapeutic lifestyle change decrease LDL cholesterol level without increasing CPK or pain levels and may be a treatment option for dyslipidemic patients who cannot tolerate statin therapy,” (Becker et al). In this study, patients were administered 1800mg red yeast rice or placebo twice daily for 24 weeks. It was found that in the red yeast rice group, LDL decreased by 1.11 mmol/l at week 12 and by 0.90 mmol/l at week 24. Here, the placebo group experienced a drop in cholesterol, too. In the placebo group, LDL decreased by 0.28 mmol/l at week 12 and by 0.39 mmol/l at week 24. Most importantly, LDL cholesterol level was significantly lower in the red yeast rice group than in the placebo group at both weeks 12 and 24 (Becker et al).


Garlic, too is known to help lower cholesterol. In one study, rats were fed a high cholesterol diet and treated with tender cluster bean and garlic. The combination forced a 56% decrease in serum cholesterol. In addition, “Biliary secretion of bile acids was increased by cluster bean and garlic,” (Pande, Srinivasan). In another study, rats were fed either 3 or 10 mg garlic and it was observed the 10mg of garlic was more effective at reducing the level of cholesterol than 3mg garlic. These results were found to be highly significant. Garlic was also found to work through mechanism of HMGCo-A reductase (Farnaz et al).




David J. Becker, MD; Ram Y. Gordon, MD; Steven C. Halbert, MD; Benjamin French, PhD; Patti B. Morris, RD; and Daniel J. Rader, MD. Red Yeast Rice for Dyslipidemia in Statin-Intolerant Patients: A Randomized Trial. Annals of Internal Medicine. 2009;150(12):830-839.


Rafe Bundy, Ann F. Walkera, Richard W. Middleton, Carol Wallisa, Hugh C.R. Simpson. Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults: A randomized, double blind placebo controlled trial. Phytomedicine. Volume 15, Issue 9, 3 September 2008, Pages 668–675


Saba Farnaz, Mohammad Zahid Qamar, Sabiha Karim, Rukhshan Khurshid. Effect of feeding garlic (Allium sativum) on body weight and serum cholesterol levels in rats. Pak J Physiol 2011; 7(1)


Canan Küçükgergin, A. Fatih Aydın, Gül Özdemirler-Erata, Güldal Mehmetçik, Necla Koçak-Toker, Müjdat Uysal. Effect of Artichoke Leaf Extract on Hepatic and Cardiac Oxidative Stress in Rats Fed on High Cholesterol Diet. Biological Trace Element Research. June 2010, Volume 135, Issue 1-3, pp 264-274


John C. LaRosa, M.D., Scott M. Grundy, M.D., Ph.D., David D. Waters, M.D., Charles Shear, Ph.D., Philip Barter, M.D., Ph.D., Jean-Charles Fruchart, Pharm.D., Ph.D., Antonio M. Gotto, M.D., D.Phil., Heiner Shubhra Pande, Krishnapura Srinivasan. Potentiation of the hypolipidemic influence of dietary tender cluster bean (Cyamopsis tetragonoloba) by garlic in cholesterol fed rats. Food Chemistry. Volume 133, Issue 3, 1 August 2012, Pages 798–805


Centers for Disease Control and Prevention (CDC). High Cholesterol Facts. http://www.cdc.gov/cholesterol/facts.htm. Accessed 6/5/2015.


NIH Medline Plus. Cholesterol Levels: What you need to know. http://www.nlm.nih.gov/medlineplus/magazine/issues/summer12/articles/summer12pg6-7.html. Accessed 6/2/2015